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Dr. Casimiro is an Assistant Professor at Thomas Jefferson University. For the last 10 years he has been working on breast cancer from a novel perspective. He has experience in mouse model systems of human disease and extensive molecular biology expeience. He was the first to identify a novel mechanism involving the interaction of the cell cycle and metabolism, contributing to a manuscript showing that mitochondrial function is regulated by a key human breast oncogene, cyclin D1. His recent publication in Journal of Clinical Investigation concerns non-canonical roles for cyclin D1, he has identified a novel role for cyclin D1 in promoting chromosomal instability. His studies show that cyclin D1 promotes a transcriptional programme that governs chromosomal instability. Cyclin associates with genes that promote CIN, induces aneuploidy in fibroblasts and correlates with CIN in human breast cancer luminal B subtypes.


Selected Publications

1.     Casimiro, M. and Rodriguez, O.,Pootrakul, L., Aventian, M., Lushina, N, Cromelin, C., Ferzli, G., Johnson, K., Fricke, S., Diba, F., Kallakuri, B., Ohanyerenwa, C., Chen, M., Ostrowski, M., Hung, M., Rabbani, S., Datar, R., Cote, R., Pestell, R., and Albanese, C. (2007) ErbB-2 Induces the Cyclin D1 Gene in Prostate Epithelial Cells in vitro and in vivo. Cancer Research, 67(9):4364-4372.

2.     Casimiro, M.C., Crosariol, M., Loro, E., Ertel, A., Yu, Z., Dampier, W., Saria, E., Papanikolaou, A., Stanek, T., Li, Z, Wang, C., Fortina, P., Addya, S., Tozeren, A., Knudsen, E.S., Arnold, A. and Pestell, R.G. ChIP-Sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. Journal of Clinical Investigation. 2013 May 1;123(5):2332.

3.     Casimiro, M.C., Wang, C., Li, Z., Di Sante, G., Willmart, N.E., Addya, S., Chen, L., Liu, Y., Lisanti, M.P., Pestell, R.G. Cyclin d1 determines estrogen signaling in the mammary gland in vivo. Molecular Endocrinology. 2013 Sep;27(9):1415-28.

4.     Ju, X. and Casimiro, M.C., Gormley, M., Meng, H., Jiao, X., Katiyar, S., Crosariol, M., Chen, K., Wang, M., Quong, A.A., Lisanti MP, Ertel A, Pestell RG. Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint. Cancer Research. 2014 Jan 15; 74(2):508-19.

5.     Casimiro MC, Di Sante G, Crosariol M, Loro E, Dampier W, Ertel A, Yu Z, Saria EA, Papanikolaou A, Li Z, Wang C, Addya S, Lisanti MP, Fortina P, Cardiff RD, Tozeren A, Knudsen ES, Arnold A, Pestell RG. Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis. Oncotarget. 2015 Apr 20;6(11):8525- 38.

6.     Casimiro MC, Di Sante G, Ju X, Li Z, Chen K, Crosariol M, Yaman I, Gormley M, Meng H, Lisanti MP, Pestell RG. Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells. Cancer Res. 2016 Jan 15;76(2):329-38

7.     Casimiro MC and Di Sante, G et, al. Cyclin D1 Restrains Oncogene-Induced Autophagy: Implications for cyclin D1 regulation of the Ampk-Lkb1 signaling axis. Cancer Research. 2017 In Press